Interpro Domain Annotation logo

Interpro Domain Annotation

Organization
ai4protein
interpro_domain_annotation

InterPro domain/family annotation via VenusFactory download tools. Use when the user needs domain boundaries, family membership, or UniProt→InterPro annotations for engineering target selection. Do NOT use for pathway enrichment (string_database / kegg_database) or kinetic parameters (brenda_database).

Overview

Publisherai4protein
RepositoryVenusFactory2
Skill nameinterpro_domain_annotation
Stars
255
Forks
37
Bundled files
Instructions only
LicenseApache-2.0
Links
  • Markdown instructions

    A SKILL.md file the model loads on demand, so it only costs tokens when a request actually matches.

  • Works with any LLM

    AI skills are plain Markdown, not provider-specific code, so this works with GPT, Claude, Gemini, Grok, or a local model.

  • Self-contained

    Everything the model needs lives in the instructions — no extra files to sync.

  • Open source

    Published by ai4protein on GitHub. Read the source before you install it.

Installation

Install the Interpro Domain Annotation AI skill in TypingMind to use it with any LLM, or drop it into another agent that reads SKILL.md.

1

Install in TypingMind

TypingMind installs a skill straight from its GitHub folder — it reads SKILL.md, bundles the resource files, and stores the result locally.

  1. Open the app and go to Plugins → Skills.
  2. Choose "Install from GitHub".
  3. Paste the skill folder URL below and confirm.
    https://github.com/ai4protein/VenusFactory2/tree/main/src/agent/skills/interpro_domain_annotation
  4. Enable the skill in any chat where you want it available.
Plugins → Skills → Add skill → From GitHub URL, then paste the folder URL and press Continue.
2

Install in another agent

Any agent that reads the Agent Skills format can use this skill — copy the folder into that agent's skills directory.

Claude Code — .claude/skills
git clone --depth 1 https://github.com/ai4protein/VenusFactory2.git /tmp/VenusFactory2
mkdir -p .claude/skills
cp -r /tmp/VenusFactory2/src/agent/skills/interpro_domain_annotation .claude/skills/interpro_domain_annotation
Restart Claude Code after copying so it picks up the new skill.

Use it in TypingMind

Enable Interpro Domain Annotation in any TypingMind chat and the model takes it from there. Its name and description sit in the system prompt, and the moment a request matches, the model loads the full instructions itself — you never invoke it by hand, and it costs no tokens until it is actually used.

The model loads Interpro Domain Annotation on its own as soon as a request matches it.

Works with any AI model

AI skills are plain Markdown instructions rather than provider-specific code, so Interpro Domain Annotation is not tied to the model it was written for. Install it once in TypingMind and use it with GPT-5, Claude, Gemini, Grok, DeepSeek, Mistral, Llama, or a local model you run yourself — all on your own API keys.

  • Loaded only when it is needed

    The system prompt carries just the name and description. The instructions are fetched on the first matching request, so an idle skill costs nothing.

  • Switch models mid-chat

    Because the skill is instructions rather than code, changing model does not break it — the next model reads the same SKILL.md.

Skill instructions

This is the SKILL.md content the model loads. Read it before installing — a skill is instructions your model will follow.

InterPro Domain Annotation

Overview

Retrieves InterPro entry metadata, UniProt-linked annotations, and protein lists. Prefer these hub tools over ad-hoc HTTP in agent_generated_code.

Project Tools (VenusFactory2)

ToolArgsWhen
download_interpro_metadata_by_idinterpro_id, out_dirKnown IPR / entry id
download_interpro_annotations_by_uniprot_iduniprot_id, out_dirDomains on a protein
download_interpro_proteins_by_idinterpro_id, out_dir, pagination argsMembers of a family
download_interpro_uniprot_list_by_idinterpro_id, out_dirUniProt accessions for an entry
download_uniprot_meta_by_iduniprot_id, out_pathCross-check function/GO

Workflow

  1. If user has UniProt accession → download_interpro_annotations_by_uniprot_id.
  2. For a specific InterPro id → metadata + optional protein list.
  3. Before proposing mutations in catalytic triads, confirm the domain via InterPro + UniProt meta.
  4. Optional: map domains onto structure via protein_structure_pipeline + residue indices.

Common mistakes

  • Treating InterPro ids as UniProt accessions.
  • Editing conserved catalytic residues without reading annotation evidence.

Frequently asked questions

What does the Interpro Domain Annotation AI skill do?

InterPro domain/family annotation via VenusFactory download tools. Use when the user needs domain boundaries, family membership, or UniProt→InterPro annotations for engineering target selection. Do NOT use for pathway enrichment (string_database / kegg_database) or kinetic parameters (brenda_database).

Why use Interpro Domain Annotation on TypingMind?

Because you install it once and use it with any model. Interpro Domain Annotation is plain Markdown rather than provider-specific code, so the same skill runs on GPT-5, Claude, Gemini, Grok, or a local model — and you can switch model mid-chat without it breaking. TypingMind runs on your own API keys, so you pay providers directly instead of a per-seat subscription, and your skills and chats stay in your own storage.

How do I install Interpro Domain Annotation in TypingMind?

Open Plugins → Skills → Install from GitHub in TypingMind and paste https://github.com/ai4protein/VenusFactory2/tree/main/src/agent/skills/interpro_domain_annotation. TypingMind reads its SKILL.md and installs it as a skill you can enable per chat.

Which AI models can use Interpro Domain Annotation?

Any model you connect in TypingMind. AI skills are plain Markdown instructions rather than provider-specific code, so GPT, Claude, Gemini, Grok, and local models can all load this skill when a request matches it.

How many AI models can I use with Interpro Domain Annotation?

As many as you like. As long as a model supports skills, you can use Interpro Domain Annotation with it — GPT, Claude, Gemini, Grok, DeepSeek, Mistral, Llama and more — all on TypingMind with your own API keys.

Is the Interpro Domain Annotation AI skill free?

Yes. It is published on GitHub by ai4protein under the Apache-2.0 license. You only pay your own AI provider for the tokens you use.

What are AI skills?

An AI skill is a reusable instruction bundle that teaches an AI model how to do one specific task. It follows the open Agent Skills format: a SKILL.md file with a name and description, plus any scripts, templates or reference files the model may need. The model reads the instructions only when your request matches the skill, so an installed skill costs nothing until it is used.

How are AI skills different from plugins or MCP servers?

A plugin or MCP server gives a model new tools to call — code that runs somewhere and returns a result. An AI skill gives the model knowledge and process instead: how to approach a task, which steps to follow, what good output looks like. Skills are plain Markdown, so they need no server, no API key and no runtime, and they work with any model.

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