Evo Proteomics Workbook

Community

Zhang-Henry

evo-proteomics-workbook

Fills a proteomics Task sheet with INDEX-MATCH expression lookups, group statistics (AVERAGE/STDEV for Control vs Treated), and fold change formulas (Log2FC and FC). Discovers layout at runtime from the workbook itself. Use when a protein_expression.xlsx has Task and Data sheets requiring two-way lookups and differential expression calculations.

Overview

Publisher	Zhang-Henry
Repository	`CoEvoSkills`
Skill name	`evo-proteomics-workbook`
Stars	83
Forks	9
Bundled files	1
License	Apache-2.0
Links	Skill source Repository Homepage

Markdown instructions
A SKILL.md file the model loads on demand, so it only costs tokens when a request actually matches.
Works with any LLM
AI skills are plain Markdown, not provider-specific code, so this works with GPT, Claude, Gemini, Grok, or a local model.
1 bundled files
Scripts, templates, and references the model can read while it works. Files are read-only and never executed.
Open source
Published by Zhang-Henry on GitHub. Read the source before you install it.

Installation

Install the Evo Proteomics Workbook AI skill in TypingMind to use it with any LLM, or drop it into another agent that reads SKILL.md.

Install in TypingMind

TypingMind installs a skill straight from its GitHub folder — it reads SKILL.md, bundles the resource files, and stores the result locally.

Open the app and go to Plugins → Skills.
Choose "Install from GitHub".
Paste the skill folder URL below and confirm.
https://github.com/Zhang-Henry/CoEvoSkills/tree/main/artifacts/skills/protein-expression-analysis/evo-proteomics-workbook
Enable the skill in any chat where you want it available.

Store

Installed

Skills

Add skills

Import one or more skills from a public GitHub folder or a local .skill or .zip archive, or SKILL.md file.

From GitHub URLFrom .skill, .zip, or SKILL.md

GitHub repo or folder

https://github.com/Zhang-Henry/CoEvoSkills/tree/main/artifacts/skills/protein-expression-analysis/evo-proteomics-workbook

Points to a single skill folder, or any folder that contains multiple skills. Public repos only.

CancelContinue

Plugins → Skills → Add skill → From GitHub URL, then paste the folder URL and press Continue.

Install in another agent

Any agent that reads the Agent Skills format can use this skill — copy the folder into that agent's skills directory.

Claude Code — .claude/skills

git clone --depth 1 https://github.com/Zhang-Henry/CoEvoSkills.git /tmp/CoEvoSkills
mkdir -p .claude/skills
cp -r /tmp/CoEvoSkills/artifacts/skills/protein-expression-analysis/evo-proteomics-workbook .claude/skills/evo-proteomics-workbook

Restart Claude Code after copying so it picks up the new skill.

Use it in TypingMind

Enable Evo Proteomics Workbook in any TypingMind chat and the model takes it from there. Its name and description sit in the system prompt, and the moment a request matches, the model loads the full instructions itself — you never invoke it by hand, and it costs no tokens until it is actually used.

The model loads Evo Proteomics Workbook on its own as soon as a request matches it.

Works with any AI model

AI skills are plain Markdown instructions rather than provider-specific code, so Evo Proteomics Workbook is not tied to the model it was written for. Install it once in TypingMind and use it with GPT-5, Claude, Gemini, Grok, DeepSeek, Mistral, Llama, or a local model you run yourself — all on your own API keys.

Loaded only when it is needed
The system prompt carries just the name and description. The instructions are fetched on the first matching request, so an idle skill costs nothing.
Switch models mid-chat
Because the skill is instructions rather than code, changing model does not break it — the next model reads the same SKILL.md.

Skill instructions

This is the SKILL.md content the model loads. Read it before installing — a skill is instructions your model will follow.

Proteomics Workbook Skill

This skill automates filling a proteomics analysis workbook with formulas:

Expression Lookups (C11:L20): INDEX-MATCH formulas to pull values from Data sheet
Group Statistics (B24:K27): AVERAGE and STDEV for Control and Treated groups
Fold Change (rows 32-41): Log2 FC = Treated Mean - Control Mean; FC = 2^(Log2FC)

Usage

python
import sys
sys.path.insert(0, '/app/environment/skills/evo-proteomics-workbook/scripts')
from utils import run_end_to_end

success = run_end_to_end('/root/protein_expression.xlsx')
if success:
    print('Task completed successfully')
else:
    print('Validation failed - check errors above')

Key Functions

discover_task_layout(ws_task) - Discovers proteins, samples, groups, and cell ranges
discover_data_layout(ws_data) - Builds protein-row and sample-column indices
write_expression_formulas(ws_task, task_layout, data_layout) - INDEX-MATCH formulas
write_statistics_formulas(ws_task, task_layout) - AVERAGE/STDEV per protein per group
write_fold_change_formulas(ws_task, task_layout) - Log2FC and FC formulas
recalculate_with_libreoffice(filepath) - Headless recalculation
validate_workbook(filepath) - Checks all output cells for numeric values
run_end_to_end(input_path, output_path=None) - Full pipeline

Design Notes

All layouts discovered at runtime from the workbook
Formulas reference cells, not hard-coded values
Statistics reference expression cells in the Task sheet
Control/Treated group membership read from row 9
LibreOffice recalculates cached formula values
Validation checks for formula errors (#REF!, #NAME?, etc.)

Bundled files

The model reads these on demand while the skill is loaded. They are exposed as readable files and are never executed.

scripts/utils.py12 KB

Frequently asked questions

What does the Evo Proteomics Workbook AI skill do?

Why use Evo Proteomics Workbook on TypingMind?

Because you install it once and use it with any model. Evo Proteomics Workbook is plain Markdown rather than provider-specific code, so the same skill runs on GPT-5, Claude, Gemini, Grok, or a local model — and you can switch model mid-chat without it breaking. TypingMind runs on your own API keys, so you pay providers directly instead of a per-seat subscription, and your skills and chats stay in your own storage.

How do I install Evo Proteomics Workbook in TypingMind?

Open Plugins → Skills → Install from GitHub in TypingMind and paste https://github.com/Zhang-Henry/CoEvoSkills/tree/main/artifacts/skills/protein-expression-analysis/evo-proteomics-workbook. TypingMind reads its SKILL.md and bundles its files and installs it as a skill you can enable per chat.

Which AI models can use Evo Proteomics Workbook?

Any model you connect in TypingMind. AI skills are plain Markdown instructions rather than provider-specific code, so GPT, Claude, Gemini, Grok, and local models can all load this skill when a request matches it.

How many AI models can I use with Evo Proteomics Workbook?

As many as you like. As long as a model supports skills, you can use Evo Proteomics Workbook with it — GPT, Claude, Gemini, Grok, DeepSeek, Mistral, Llama and more — all on TypingMind with your own API keys.

Is the Evo Proteomics Workbook AI skill free?

Yes. It is published on GitHub by Zhang-Henry under the Apache-2.0 license. You only pay your own AI provider for the tokens you use.

What are AI skills?

An AI skill is a reusable instruction bundle that teaches an AI model how to do one specific task. It follows the open Agent Skills format: a SKILL.md file with a name and description, plus any scripts, templates or reference files the model may need. The model reads the instructions only when your request matches the skill, so an installed skill costs nothing until it is used.

How are AI skills different from plugins or MCP servers?

A plugin or MCP server gives a model new tools to call — code that runs somewhere and returns a result. An AI skill gives the model knowledge and process instead: how to approach a task, which steps to follow, what good output looks like. Skills are plain Markdown, so they need no server, no API key and no runtime, and they work with any model.

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Overview

Installation

Install in TypingMind

Install in another agent

Use it in TypingMind

Works with any AI model

Skill instructions

Proteomics Workbook Skill

Usage

Key Functions

Design Notes

Bundled files

Frequently asked questions

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